Organocatalyzed Asymmetric Friedel‐Crafts Reactions: An Update
نویسندگان
چکیده
منابع مشابه
Organocatalyzed Intramolecular Carbonyl-Ene Reactions.
An organocatalyzed intramolecular carbonyl-ene reaction was developed to produce carbocyclic and heterocyclic 5- and 6-membered rings from a citronellal-derived trifluoroketone and a variety of aldehydes. A phosphoramide derivative was found to promote the cyclization of the trifluoroketone, whereas a less acidic phosphoric acid proved to be a superior catalyst for the aldehyde substrates.
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The ubiquitous presence of spirooxindole architectures with several functionalities and stereogenic centers in bioactive molecules has been appealing for the development of novel methodologies seeking their preparation in high yields and selectivities. Expansion and refinement in the field of asymmetric organocatalysis have made possible the development of straightforward strategies that addres...
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Reactions that form a C-C bond make up a foundational pillar of synthetic organic chemistry. In addition, organocatalysis has emerged as an easy, environmentally-friendly way to promote this type of bond formation. Since around 2000, organocatalysts have been used in a variety of C-C bond-forming reactions including Michael and aldol additions, Mannich-type reactions, and Diels-Alder reactions,...
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Various organocatalysts have been developed for the aldol reaction but particular attention has been paid to prolinamide derivatives. They are easy to prepare and their catalytic activity can be readily tuned through structural modification. In this review, the comparison of catalytic activities between prolinethioamides and their respective amides in direct asymmetric aldol reactions is presen...
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ژورنال
عنوان ژورنال: The Chemical Record
سال: 2019
ISSN: 1527-8999,1528-0691
DOI: 10.1002/tcr.201800190